http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2006/03/28/GOODMAN.TMPWell, this isn't technically cancelled, but no network would be sane to pick up such a great show without the head honcho who helped make it so great. 53 episodes of brillance, and it's done.
Bob Factoid: The fishercat is the only creature known to have gone completely insane chasing its own tail.